聚硅氧烷的亲水改性及其在角膜接触镜中的应用

doi:10.16597/j.cnki.issn.1002-154x.2025.05.004

聚硅氧烷的亲水改性及其在角膜接触镜中的应用

律斯宇 张雪勤*

（bet体育365官网网站 bet体育365官网网站，南京 211189）

摘 要 作者将亲水性的聚乙二醇（PEG）链段和甲基丙烯酸缩水甘油酯（GMA）引入到聚二甲基硅氧烷（PDMS）的主键，设计合成了一种新型结构的双亲性有机硅大分子单体 PDMS-GMA，将其与亲水性单体共聚，制备了硅水凝胶角膜接触镜，在提高镜片透氧性的同时改善了其表面亲水性。重点研究了双亲性大分子硅单体含量对镜片平衡含水率、接触角、透氧值、透光率等性能的影响。结果表明，亲水基团的引入显著提高了角膜接触镜的亲水性和含水率，随着 PDMS-GMA 含量的增加，镜片的含水率逐渐增加，可达 75.98%，接触角由 87.73°降低至 23.47°，同时透氧值从 74 barrer 提升至 92 barrer(1 barrer=7.35×10${}^{-6}$−6 m${}^2$2·s·kg${}^{-1}$−1)。研究结果为新型有机硅单体和角膜接触镜的研制提供了新的思路。

关键词 角膜接触镜 硅水凝胶 聚硅氧烷 亲水改性

Hydrophilic Modification of Polysiloxane and Its Application in Contact Lenses

LYU Siyu ZHANG Xueqin*

(School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189, China)

Abstract This study introduces hydrophilic polyethylene glycol (PEG) segments and glycidyl methacrylate (GMA) into the main chain of polydimethylsiloxane (PDMS), designing and synthesizing a novel amphiphilic organosilicon macromonomer PDMS-GMA. This macromonomer is copolymerized with hydrophilic monomers to prepare silicone hydrogel contact lenses, which improved the surface hydrophilicity of the lenses while increasing their oxygen permeability. The study focuses on the effects of the amphiphilic siloxane macromonomer content on the equilibrium water content, contact angle, oxygen permeability, and transmittance of the lenses. Results show that the introduction of hydrophilic groups significantly improves the hydrophilicity and water content of the contact lenses. As the PDMS-GMA content increases, the water content of the lenses gradually rises, reaching 75.98%, while the contact angle decreases from 87.73° to 23.47°. Simultaneously, the oxygen permeability increases from 74 barrer to 92 barrer(1 barrer=7.35×10${}^{-6}$−6 m${}^2$2·s·kg${}^{-1}$−1). The findings provide new insights for the development of novel organosilicon monomers and contact lenses.

Keywords contact lenses silicone hydrogel polysiloxane hydrophilic modification